Lignocaine Hydrochloride Injection Overview
Heart rhythm abnormalities are treated with lignocaine hydrochloride Injection. Electrical impulses governed by the nervous system are responsible for the heart’s pumping action. The heart’s capacity to efficiently pump blood throughout the body is impacted if its pumping action is substantially disrupted.
The mechanism of action of lignocaine hydrochloride is to lessen the heart muscle’s sensitivity to electrical impulses. This helps to restore a regular heart rhythm by slowing the conduction of electrical signals in the heart muscle. This facilitates the heart’s efficient circulation of blood throughout the body.
Dose Advice for Injection
Lower bolus doses may be necessary for patients with impaired cardiac function (such as congestive heart failure or cardiogenic shock).Patients who are not candidates for oral antiarrhythmic therapy and whose arrhythmia tends to return after a single injection should consider intravenous infusion.
Uses of Lignocaine Hydrochloride Injection
Adults:
- The usual dose is lignocaine 50 to 100 mg administered intravenously under ECG monitoring. The dose may be injected at a rate of approximately 25 to 50 mg (2.5 to 5.0 mL of the lignocaine 1% solution or 1.25 to 2.5 mL of the 2% solution) per minute.
- If the initial dose of 50 to 100 mg does not produce the desired response, a second dose may be given after five minutes. No more than 200 to 300 mg of lignocaine should be administered during a one hour period.
- Intravenous infusions of lignocaine may be administered at a rate of 1 to 4 mg/minute (20 to 50 mcg/kg/minute). Intravenous infusions must be given under ECG monitoring to avoid potential overdosage and toxicity. The infusion should be terminated as soon as the patient’s cardiac rhythm appears to be stable or at the earliest signs of toxicity.
Children:
- A suggested paediatric dose is a loading dose of lignocaine 0.5 to 1 mg/kg repeated if necessary up to 3 to 5 mg/kg, followed by continuous infusions of 10 to 50 microgram/kg/minute.
Elderly:
- dose may need to be adjusted depending on age and comorbidities.
