Description
They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Gliclazide is a sulfonylurea which works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Pioglitazone is a thiazolidinedione which increases insulin sensitivity. Metformin is a biguanide. It works by lowering glucose production in the liver, delaying glucose absorption from intestines and further increasing the body’s sensitivity to insulin.